-the official journal of the Society for Inherited Metabolic Disorders

Molecular Genetics and Metabolism is a contribution to the understanding of the metabolic basis of disease. The journal publishes articles describing investigations that use the tools of biochemistry and molecular biology for studies of normal and diseased states. In addition to original research articles, occasional minireviews reporting timely advances as well as brief communications and letters to the editor are considered.

* Inherited Metabolic Diseases
- Biochemical studies of primary enzymatic defects
- Molecular genetic analyses of mutations
- Pathogenesis of these disorders, including not only primary but also secondary metabolic alterations

* Intercellular and Intracellular Metabolic Relationships
- Biochemical interactions between cells
- Functional roles of and interactions between subcellular compartments and distinct regions within these cellular spaces, termed microcompartments
- Metabolic relations between individual enzymes and pathways

* Cellular Catalysts
- Protein and nonprotein catalysts in normal and deranged cellular metabolism
- Relationships between the structure and function of catalytic molecules
- Interaction of these catalysts with other cellular components

* Disease Pathogenesis
- Underlying mechanisms of inherited and acquired diseases
- Relationships between genotype and phenotype at the biochemical and molecular levels
- Strategies for the metabolic improvement of patients through classical drug and dietary intervention, as well as more novel approaches such as transplantation and gene therapy