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| Translational and Experimental Clinical Research |
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※해외주문 도서 안내 :
- 해외 및 국내 입고 사항에 따라 2~8주 이상 소요될 수 있으며. 취소 및 반품이 불가능합니다.
- 해외주문도서는 해외 출판사 사정에 의해 품절/지연될수 있습니다. |
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※교환 및 반품안내 :
- 교환이나 반품시 상품 수령후 3일이내 교환이나 반품 의사를 알려주시고 일주일이내에 저희쪽으로 상품이 입고되어야합니다.
시일이 경과되면 반품이 불가합니다.
- 변심에 의한 교환이나 반품시, 배송비는 고객님께서 부담하시며, 오배송이나 상품 불량시에는 무료 교환이 가능합니다.
- 반품시에는 반품상품 검수후 카드 취소를 해드리거나 통장,적립금등으로 환불 조치 해 드립니다. |
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※배송안내 :
- 제주도및 도서산간지역은 택배비가 추가될수 있습니다. |
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This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues.
Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.
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SECTION I:Planning and Designing Clinical Research 1
Defining the Research Question 3
Searching the Literature 15
Variables and Measurements 31
Study Eligibility and Participant Selection 45
Recruiting Research Participants 54
Reducing Bias 67
Observational Study Designs 73
Experimental Study Designs 84
Estimating Sample Size 97
Database Development 113
Case Report Form Development 122
Data Collection and Quality Control 136
Monitoring Experimental Interventions 152
SECTION II:Special Topics 161
Responsible Conduct of Research 163
Regulatory Oversight 176
Funding Clinical Research 189
Research Budgeting 198
"Small" Clinical Experiments 203
Clinical Studies in Pediatric Minority Populations 209
Pharmacokinetics and Pharmacodynamics 212
Gene Therapy and Pharmacogenomic Studies 223
Preparing for Gene Therapy Studies 237
SECTION III:Analyzing and Reporting Results 247
Overview: Hypothesis Testing and Summary Statistics 249
Group Comparisons 258
Regression 271
Multivariate Analysis 284
Biostatistical Consulting 297
Statistical Computing 303
Presenting Data in Manuscripts 308
Visual Presentation of Data 320
SECTION IV:Modern Techniques of Translational Clinical Research 331
Fundamentals of Gene Expression 333
Identifying Mutations and Polymorphisms 343
Cloning Methods 356
Transcriptional Profiling 369
Proteomics 385
Cell and Tissue Imaging Techniques 396
Non-Imaging Cell and Tissue Techniques and Tissue Banking 413
Evaluating Substrate Metabolism 435
Medical Images as Scientific Data 450Index 465 |
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등록된 서평이 없습니다. |
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과별도서목록
