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Angiogenesis is the development of new blood vessels from an existing vascular bed, which normally happens only during embryonic development, the female reproductive cycle, and wound repair. Persistent and unregulated angiogenesis is associated with pathological conditions such as cancer and atherosclerosis, while too little can lead to chronic pressure ulcers and other conditions. Here scientists from throughout the industrialized world report on developments in controlling vascular development that are leading to new therapeutic approaches to both types of disorder. They describe the basic science, experimentation, and clinical trials.

Book Info

National Institutes of Health, Bethesda, MD. Covers recent progress in basic and applied research in angiogenesis. Discusses angiogenic and antiangiogenic agents in development and in clinical trials and considers the prospects of gene therapy in the development of angiotherapy. For researchers. DNLM: Neovascularization, Pathologic.

Foreword
Preface
List of Contributors
I Concepts
1 Vasculogenesis and Angiogenesis 1
2 Angiogenesis-Regulating Cytokines 7
3 The Angiopoietins 41
4 Regulation of Vascular Morphogenesis by Extracellular Matrix Proteins 51
II Angiogenesis in Health and Disease
5 Integrin Receptors and the Regulation of Angiogenesis 67
6 Vasoactive Peptides in Angiogenesis 81
7 Angiogenesis in Wound Healing and Surgery 105
8 Angiogenesis and Vascular Endothelial Growth Factor (VEGF) in Reproduction 115
9 Rheumatoid Arthritis: A Target for Anti-Angiogenic Therapy? 129
10 Diagnostic and Prognostic Significance of Tumor Angiogenesis 151
III Stimulation of Angiogenesis [Therapeutic Angiogenesis]
11 Hyaluronan Oligosaccharides Promote Wound Repair: Its Size-Dependent Regulation of Angiogenesis 177
12 Role of Thymic Peptides in Wound Healing 189
13 Angiogenesis and Growth Factors in Ulcer Healing 199
14 Angiogenesis in Skeletal and Cardiac Muscle: Role of Mechanical Factors 213
15 Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease 249
16 Therapeutic Angiogenesis for the Heart 279
17 Contact-Guided Angiogenesis and Tissue Engineering 295
IV Anti-Angiogenesis 315
18 Inhibitors of Matrix Metalloproteinases 315
19 Control of Angiogenesis by Microbial Products 329
20 Interaction of Angiogenic Growth Factors with Endothelial Cell Heparan Sulfate Proteoglycans: Implications for the Development of Angiostatic Compounds 357
21 2-Methoxyestradiol: A Novel Endogenous Chemotherapeutic and Anti-Angiogenic Agent 387
V Novel Targets
22 Receptor Tyrosine Kinases in Angiogenesis 409
23 Targeting Gene Therapy to the Tumor Vasculature 453
24 Antibody Targeting of Tumor Vasculature 475
25 Endothelial Monocyte-Activating Polypeptide II: A Novel Injury Signal? 491
26 CD 105 Antibody for Targeting of Tumor Vascular Endothelial Cells 499
VI Angiotherapy in the Clinic
27 Design of Pharmacological and Diagnostic Strategies for Angiogenesis-Dependent Diseases 517
28 Design of Clinical Trials for Anti-Angiogenics 527
29 Angiogeneis Therapies: Concepts, Clinical Trials, and Considerations for New Drug Development 547
30 Angiostatin and Endostatin: Recent Advances in Their Biology, Pharmacokinetics, and Potential Clinical Applications 573
Index 601