Book Info

Univ. of Pennsylvania, Philadelphia. Pocket guide for students, physicians, and allied health professionals, presents the essential data needed to understand the principles of antimicrobial pharmacology, as well as the optimal use of antimicrobials in daily practice. Hardcover, softcover available.

Book Description

This concise handbook provides key tabular data and useful appendices covering all aspects of antimicrobial pharmacology. It provides the user with clear and quick access to medical information pertaining to antibiotics and infectious diseases. The textual discussions are organized according to drug classes, with special mention of any unusual or exceptional information pertaining to the specific agents. Each discussion is organized into 5 parts covering the structure and mechanism of action, the spectrum of activity, pharmcokinetics, adverse effects, and resistance. Further, a complete overview is presented for each of the 20 drug classes. To reinforce the "vertical" presentation of each class of drugs, a comparative discussion of the "horizontal" relationships between the corresponding blocks in different drug classes is provided. This book is essential for all physicians utilizing antimicrobial agents in the treatment of their patients.

Preface
1 Introduction 1
1.1 Measures of Antibiotic Effect 1
1.2 Antibiotic Administration 2
1.3 Distribution and Elimination 4
1.4 Sensitivity Testing 6
1.5 Dose-Response Relationships 10
1.6 Resistance 11
2 Antibacterial Agents 13
2.1 Cell Wall Active Agents 13
2.2 Antifolate Agents 28
2.3 Aminoglycosides/Aminocyclitols 32
2.4 Antiribosomal Agents 35
2.5 Topoisomerase Inhibitors 47
2.6 Miscellaneous Agents 49
2.7 Antimycobacterial Agents 54
2.8 Investigational Agents 60
2.9 Combination Antibacterial Therapy 62
2.10 Choosing and Planning Antimicrobial Therapy 62
3 Antifungal Agents 65
3.1 Amphotericin 65
3.2 Flucytosine 68
3.3 Ergosterol Synthesis Inhibitors: Allylamines 70
3.4 Ergosterol Synthesis Inhibitors: Azoles 70
3.5 Caspofungin 72
3.6 Griseofulvin 72
4 Antiparasitic Agents 73
4.1 Antiprotozoan Agents 73
4.2 Antihelminthic Agents 83
5 Antiviral Agents 87
5.1 Antiherpesvirus Agents 87
5.2 Antiinfluenzavirus Agents 95
5.3 Anti-HIV Agents 98
5.4 Miscellaneous Agents 105
6 Immunomodulators and Immunizing Agents 109
6.1 Immunomodulators 109
6.2 Immunization 113
Index 123