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The pharmacology and metabolism of benzodiazepines (LDBs) and GHB are given as background to this text which has been designed to help the toxicologist develop methodologies for detecting these drugs. The chapters describe the immunoassay detection of LDBs, the current state of testing, the methods for detecting Rohypnol and other LDBs with mass spectrometry, the detection of LDBs in hair, and the pharmacology and detection of GHB. A case study of the presence of drugs in cases of alleged sexual assault concludes the volume. The contributors are affiliated with private and academic laboratories in the US and Western Europe.

Book Info

Roche Diagnostics Corp., Indianapolis, IN. Provides background on the pharmacology and metabolism on LDB and GHB helping the toxicologist develop methodologies to enable better detection of these drugs in various body fluids, as well as in hair. Gives guidance on drugs used in cases of sexual assault. DNLM: Body Fluids-chemistry.

Book Description

Roche Diagnostics Corp., Indianapolis, IN. Provides background on the pharmacology and metabolism on LDB and GHB helping the toxicologist develop methodologies to enable better detection of these drugs in various body fluids, as well as in hair. Gives guidance on drugs used in cases of sexual assault. DNLM: Body Fluids-chemistry.

Preface
Contributors
Ch. 1 Pharmacology of Flunitrazepam and Other Benzodiazepines 1
Ch. 2 Immunoassay Detection of Benzodiazepines 17
Ch. 3 Analysis of Flunitrazepam and Its Metabolites in Biological Specimens 33
Ch. 4 Analysis of Selected Low-Dose Benzodiazepines by Mass Spectrometry 53
Ch. 5 Identification of Benzodiazepines in Human Hair: A Review 77
Ch. 6 [gamma]-Hydroxybutyric Acid and Its Analogs, [gamma]-Butyrolactone and 1,4-Butanediol 95
Ch. 7 Analysis of Urine Samples in Cases of Alleged Sexual Assault: Case History 127
Index 145