From Book News, Inc.

In this text, international experts in basic and clinical science provide an account of the best current understanding of the genetics of cancer. The 24 contributions detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, skin, and in the leukemias and lymphomas. They illuminate both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms of cancer induction. They also consider the future directions of research, including the exploitation of molecular targets for developing anticancer drugs, gene therapy, and the appropriate use of molecular information in genetic counseling. Edited by Coleman (U. of North Carolina School of Medicine) and Tsongalis (Hartford Hospital).Book News, Inc.

Book Info

Univ. of North Carolina, Chapel Hill. Provides information on the current state of the art of the molecular biology of human neoplastic diseases. Also takes a look to the future of the discipline and the potential impact of scientific advances on the practice of medical oncology. For advanced graduate and medical students, researchers and residents.

Book Description

Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.

Preface
Dedication
Contributors
Pt. I Introduction
1 Cancer Epidemiology: Incidence and Etiology of Human Neoplasms 3
Pt. II Essential Concepts in Molecular Biology
2 Essential Concepts and Techniques in Molecular Biology 25
Pt. III Molecular Themes in Oncogenesis
3 Cancer Genes 45
4 Positive Mediators of Cell Proliferation in Neoplastic Transformation 65
5 Inactivation of Negative Growth Regulators During Neoplastic Transformation 81
Pt. IV Mechanisms of Mutation
6 The Role of Genomic Instability in the Development of Human Cancer 115
7 Chromosomes and Chromosomal Instability in Human Cancer 143
8 Hereditary Cancer 159
Pt. V Etiology of Human Cancers
9 Evolution of Research in Cancer Etiology 189
10 Cellular Responses to Chemical Carcinogens 203
11 Physical Agents in Human Carcinogenesis 223
12 Viral Mechanisms of Human Carcinogenesis 233
Pt. VI Human Tumor Systems
13 The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway 251
14 Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma 269
15 The Molecular Basis of Breast Carcinogenesis 347
16 The Molecular Basis of Prostate Carcinogenesis 365
17 The Molecular Basis of Lung Carcinogenesis 379
18 The Molecular Basis of Skin Carcinogenesis 407
19 The Molecular Biology of Leukemias 427
20 Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma 461
Pt. VII Future Directions
21 Cancer Genetic Counseling 477
22 Molecular Genetic Diagnosis of Inherited Cancer Predisposition 497
23 Novel Molecular Targets for Cancer Drug Discovery 521
24 Gene Therapy in the Treatment of Human Cancer 541
Index 567