This text has been written as a practical guide, based on the author’s experience over the last 40 years of daily clinical practice and aiming to place the modern approach to the management of infertility in the context of sound theory and evidence-based therapy. It provides the reader with a comprehensive classification of the causes of infertility, their investigation, and their management. This new edition covers many advances in the understanding and management of infertility and other updates to practice - for example, a greater understanding of the pathophysiology of ovarian aging and ovarian reserve testing, the classification of disorders of ovulation and management of polycystic ovary syndrome, the refinement of regimens for superovulation, improved embryo culture systems and the use of artificial intelligence for the selection of embryos, assessments for endometrial receptivity and management of recurrent implantation failure, and pre-implantation genetic testing (PGT) as a therapeutic tool opening up the possibility for aneuploidy screening, as well as the latest thoughts on nutritional health, periconception care, and the exciting new world of the microbiome.

Foreword Richard S. Legro. Preface. 1 Epidemiology of infertility, 21st Century Considerations, and the Covid-19 Pandemic. 2 Prevention of Infertility. 3 Planning a Pregnancy and Preconception Health. 4 Obesity and Reproduction.5 Investigating Infertility.6 Anovulatory Infertility and Ovulation Induction. 7 Polycystic Ovary Syndrome. 8 Premature ovarian insufficiency and oocyte donation. 9 Endometriosis. 10 Tubal Infertility, Fibroids, and uterine factors. 11 Male Factor Infertility. 12 Unexplained Infertility. 13 Assisted Conception and the regulation of ART. 14 Fertility Preservation. 15 Pre-implantation Genetic Testing and Emerging Technologies. 16 Complications of Ovarian Stimulation. 17 Counselling and Modern Families. 18 Ethical and Religious Considerations.19 Health outcomes of children born after assisted conception. 20 Management of problems in early pregnancy. 21 The spectrum of recurrent implantation failure and recurrent miscarriage. 22 Alternative Therapies and add-ons. 23 When to Stop Treatment and Other Options.Appendix: Daily Vitamin and Mineral Requirements. Further Reading and Useful Addresses. Index.