Abstract:
A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.

From Book News, Inc.
Schousboe, professor of pharmacology, and Brauner-Osborne, professor of medical chemistry, The Danish University of Pharmaceutical Sciences, Denmark, present contributions from leading neuroscience investigators combining advanced chemistry with molecular modeling to produce a collection of techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. Procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein- coupled receptors. Information about X-ray crystallographic analyses is included as well. The book's readership includes researchers in academia and industry working on the molecular pharmacology of receptors and transporters.Copyright 2004 Book News, Inc., Portland, OR

Book Info
The Danish Univ. of Pharmaceutical Sciences, Copenhagen. Provides cutting-edge techniques for using site directed mutagenesis and molecular modeling. Offers the tools needed to understand how CNS neurons communicate and promises the development of novel therapeutic agents and strategies for many neurologic diseases. For researchers. DNLM: Neuopharmacology--methods.