Book Info

Wadsworth Center and Ordway Research Institute, Albany, NY. Comprehensive reference presents the background of what stem cells are and what they can do. Discusses the role of stem cells in wound healing, tissue renewal, and regeneration of the cardiovascular and nervous systems. Features transplantation in various clinical applications.

This survey on the state-of-the-science of stem cell biology explains the origins of stem cells and describes how they function, how they can cause illness, and how they might be employed to cure or ameliorate disease. In particular, the authors discuss the roles of stem cells in development and organogenesis, in normal tissue turnover, in the repair response to injury, and in carcinogenesis. They also explain how to obtain stem cells from different organs, culture them in vitro, and manipulate them for therapeutic use.

Dedication
Preface
Contributors
1 Stem Cells: What Are They? Where Do They Come From? Why Are They Here? When Do They Go Wrong? Where Are They Going? 1
2 Stem Cells from Early Mammalian Embryos: Common Themes and Significant Differences 19
3 Embryonic Stem Cells: Isolation and Application of Pluripotent Cells from the Pregastrulation Mammalian Embryo 33
4 From Stem Cells to Functional Tissue Architecture: What Are the Signals and How Are They Processed? 45
5 Germline Stem Cells 57
6 Stem Cells and Cloning 75
7 Genomic Imprinting in Mouse Embryonic Stem and Germ Cells 81
8 Stem Cells in Amphibian Regeneration 89
9 Stem Cells in Dermal Wound Healing 101
10 Bone Marrow Mesenchymal Stem Cells 107
11 Normal and Leukemic Hematopoietic Stem Cells and Lineages 119
12 Developmental Origin of Murine Hematopoietic Stem Cells 133
13 Stromal Support of Hematopoiesis 143
14 Hematopoietic Stem Cells: Identification, Characterization, and Assays 155
15 Hematopoietic Stem Cells in Leukemia and Lymphoma 163
16 Neurons, Stem Cells, and Potential Therapies 177
17 Neural Stem Cells: From In Vivo to In Vitro and Back Again - Practical Aspects
18 Molecular Genetic Approaches in the Study of Retinal Progenitor Cells and Stem Cells 209
19 Endothelial Progenitor Cells 221
20 Development of the Cardiovascular System in Embryoid Bodies Derived from Embryonic Stem Cells 229
21 Transcription Factors, Growth Factors, and Signal Cascades Capable of Priming Cardiogenesis 239
22 Strategies Using Cell Therapy to Induce Cardiomyocyte Regeneration in Adults with Heart Disease 251
23 Generation and Stem Cell Repair of Cardiac Tissues 259
24 Stem Cells in Kidney Morphogenesis 267
25 Nephroblastoma: A Metanephric Caricature 277
26 Stem Cells in Nonmelanoma Skin Cancer 289
27 The Stem Cell Plasticity of Aggressive Melanoma Tumor Cells
28 Stem Cells in Glandular Organs 307
29 Gastrointestinal Stem Cells: Proliferation Kinetics and Differentiation Hierarchies 317
30 Stem Cell Origin of Cell Lineages, Proliferative Units, and Cancer in the Gastrointestinal Tract 329
31 Specification of Liver from Embryonic Endoderm 345
32 Animal Models for Assessing the Contribution of Stem Cells to Liver Development 353
33 Normal Liver Progenitor Cells in Culture 367
34 Permanent Lines of Stem Cells from the Liver 385
35 Biology of Human Liver Stem Cells 397
36 Transplantation in Hepatic Stem Cells and Potential Applications for Cell Therapy 409
37 Plasticity of Adult-Derived Pancreatic Stem Cells 417
38 Islet Cells 429
39 Mammary Epithelial Stem Cells 437
40 Morphogenesis of Prostate Cancer 445
41 Stem Cells in Lung Morphogenesis, Regeneration, and Carcinogenesis 455
42 Noninvasive Imaging in Stem Cell Therapies: Current State and Future Perspectives 473
43 What Is the Future for Stem Cell Research? Whether Entity or Function? 491
Index 501