Clinically focused and designed to provide a to-the-point overview, Glioblastoma, by Drs. Steven Brem and Kalil G. Abdullah, brings you up to date with increased understanding, new treatment protocols, and recent advances in the field. Written by contributing specialists who are global experts in their respective areas, this one-stop reference provides neurosurgeons, medical-and-radiation oncologists, neuro-oncologists, neuropathologists, internal medicine physicians, and researchers with a dependable source of information on current treatment options, tumor recurrence, and patient care.

Key Features
•Evidence for current treatment options for de novo and recurrent glioblastoma, indications for local and topical therapies, immunotherapy, gene therapy, nanotherapy, small-molecule inhibition, electric tumor treating field stimulation, and antiangiogenic therapies and the role of Avastin.


•Recent advances relating to tumor resection, such as stereotactic laser ablation, diffusion tensor imaging, and fluorescent markers.



•Prognostic molecular and genetic markers and the impact of gene mutations on survival, as well as controversies relating to pseudo-progression.



•Lessons learned from unsuccessful interventions, as well as the most promising aspects of future glioblastoma research and treatment.



•Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Part I: Disease Origins and Context



The Story of Glioblastoma: History and Modern Correlates



Epidemiology of Glioblastoma and Trends in Glioblastoma Survivorship



The Molecular Pathogenesis of Glioblastoma



Diagnostic, Prognostic, and Predictive Biomarkers for Adult and Pediatric Gliomas in Clinical Practice



Multimodality Targeting of Glioma Cells

Part II: Standards of Medical and Surgical Treatment



Current Standards of Care in Glioblastoma Therapy



Radiographic Detection and Advanced Imaging of Glioblastoma



Principles and Tenets of Radiation Treatment in



Chemotherapeutics and Their Efficacy



Anti-angiogenic Therapy for Glioblastoma



Recurrent Glioblastoma



Principles of Surgical Treatment



Awake Craniotomy for Glioblastoma



Intraoperative Imaging of Glioblastoma



Minimally Invasive Targeted Therapy for Glioblastoma Laser Interstitial Thermal Therapy (LITT)



Local and Topical Treatment of Glioblastoma



Tumor Treating Electric Fields for Glioblastoma

Part III: Scientific Advances, Future Directions, and Socioeconomic Considerations



Brain Plasticity and Reorganization Before, During, and After Glioma Reseaction



Genetically modified T-cell therapy for glioblastoma



Early Detection of Glioblastoma



Health-Related Quality of Life and Neurocognitive Functioning after Glioblastoma Treatment



Socioeconomics and Survival



National and Global Economic Implications of Glioblastoma



Lessons Learned: Clinical Trials and Other Interventions for Glioblastoma