Features

•Presents a compilation of most of the major hemorrhagic fevers caused by viruses
•Provides detailed descriptions of epidemiology, molecular pathogenesis, and host pathogen interactions
•Includes the most current information on clinical and basic science aspects
•Bridges the gap between theory and practice by including content from basic science to application





Summary


Viral hemorrhagic fevers have captured the imagination of the public and made their way into popular books and movies by virtue of their extreme virulence and mysterious origins. Since 2001, concerns have grown about the potential use of many hemorrhagic fever viruses as biological weapons. This has led to a resurgence in research to develop improved diagnostics, vaccines, and therapeutics—both for biodefense purposes and to treat naturally exposed persons. Written by international experts, Viral Hemorrhagic Fevers represents a major contribution to the virological literature and updates the state of knowledge of these dangerous illnesses.


Topics include:



•A historical perspective and information on pathogenesis and immune responses
•Animal models, which are critical to the development of vaccines and therapeutics
•The roles of high-containment facilities and specially trained scientists in research
•Prevention and control, including diagnostics and vaccine development
•Old World Lassa and Lujo viruses and the New World Junin and Machupo viruses
•Guanarito viruses and their cellular receptors
•Bunyaviruses, including Rift Valley Fever, Crimean– Congo hemorrhagic fever, and hantaviruses that cause hemorrhagic fever with renal syndrome
•The Ebola and Marburg filoviruses
•Flaviviruses, including dengue fever, yellow fever, Kyanasur Forest, Alkhurma, and Omsk hemorrhagic fever viruses and other flaviviruses with hemorrhagic potential



Virologists, clinicians, biomedical researchers, microbiologists, and others needing a rapid overview of the nature of these illnesses will find this book an essential resource on clinical and basic science aspects of many viral hemorrhagic fevers. The book will also provide researchers with a springboard to further inquiry in combating what has become a major global threat.

General Aspects

Viral Hemorrhagic Fevers: History and Definitions; Jens H. Kuhn, Anna N. Clawson, Sheli R. Radoshitzky, Victoria Wahl-Jensen,

Sina Bavari, and Peter B. Jahrling

General Disease Pathology in Filoviral and Arenaviral Infections; Louis M. Huzella, Jennifer A. Cann, Matthew Lackemeyer, Victoria Wahl-Jensen, Peter B. Jahrling, Jens H. Kuhn, and Donna L. Perry

Interaction of the Host Immune System with Hemorrhagic Fever Viruses; Gavin C. Bowick

Vascular Endothelium and Hemorrhagic Fever Viruses; Nadine A. Dalrymple, Elena Gorbunova, Irina Gavrilovskaya, and Erich R. Mackow

Vascular Endothelial Dysfunctions: Viral Attack and Immunological Defense; Jayashree Apurupa Lahoti, Ritu Mishra, and Sunit Kumar Singh

Animal Models of Viral Hemorrhagic Fevers; Amy C. Shurtleff, Travis K. Warren, Derek Morrow, Sheli R. Radoshitzky, Jens H. Kuhn, and Sina Bavari

Role of Rodents and Bats in Human Viral Hemorrhagic Fevers; Victoria Wahl-Jensen, Sheli R. Radoshitzky, Fabian de Kok-Mercado,

Shannon L. Taylor, Sina Bavari, Peter B. Jahrling, and Jens H. Kuhn

Biosafety Issues and Clinical Management of Hemorrhagic Fever Virus Infections; George F. Risi and Thomas Arminio

BSL4 Workforce Preparedness in Hemorrhagic Fever Outbreaks; Sean G. Kaufman

Major Strategies for Prevention and Control of the Viral Hemorrhagic Fevers; Matthew L. Boulton and Eden V. Wells

Practical Considerations for Collection and Transportation

of Hemorrhagic Fever Samples; Manfred Weidmann and Mandy Elschner

Laboratory Diagnosis of Viral Hemorrhagic Fevers; Miroslav Fajfr and Daniel Růžek

Vaccine Research Efforts for Hemorrhagic Fever Viruses; Shannon S. Martin and Mary Kate Hart

Specific Infections

Pathogenic Old World Arenaviruses; Jason Botten, Benjamin King, Joseph Klaus, and Christopher Ziegler

Lassa Fever; Daniel G. Bausch, Lina M. Moses, Augustine Goba, Donald S. Grant, and Humarr Khan

Lujo Virus Hemorrhagic Fever; Janusz T. Paweska, Petrus Jansen van Vuren, and Jacqueline Weyer

Receptor Determinants of Zoonosis and Pathogenesis of New World Hemorrhagic Fever Arenaviruses; Stephanie Jemielity, Michael Farzan, and Hyeryun Choe

Argentine Hemorrhagic Fever; Víctor Romanowski, Matías L. Pidre, M. Leticia Ferrelli, Cecilia Bender, and Ricardo M. Gómez

Bolivian Hemorrhagic Fever; Sheli R. Radoshitzky, Fabian de Kok-Mercado, Peter B. Jahrling, Sina Bavari, and Jens H. Kuhn

"Venezuelan" Hemorrhagic Fever; Sheli R. Radoshitzky, Fabian de Kok-Mercado, Peter B. Jahrling, Sina Bavari, and Jens H. Kuhn

Rift Valley Fever Virus and Hemorrhagic Fever; Alexander N. Freiberg and Ramon Flick

Crimean–Congo Hemorrhagic Fever Virus; Onder Ergonul

Hemorrhagic Fever with Renal Syndrome; Paul Heyman, Tatjana Avsic-Zupanc, Christel Cochez, Ana Saksida, and Ake Lundkvist

Ebola virus Infection; Anthony Griffiths, Andrew Hayhurst, Robert Davey, Olena Shtanko, Ricardo Carrion Jr., and Jean L. Patterson

Marburg Virus Disease; Steven B. Bradfute, Sina Bavari, Peter B. Jahrling, and Jens H. Kuhn

Dengue Hemorrhagic Fever; Chwan-Chuen King and Guey Chuen Perng

Yellow Fever Virus Infection; Kate D. Ryman and William B. Klimstra

Kyasanur Forest Disease; Gerhard Dobler and Frank Hufert

Alkhurma Virus Hemorrhagic Fever; Ziad A. Memish, Shamsudeen Fagbo, and Ali Zaki

Omsk Hemorrhagic Fever; Daniel Růžek, Valeriy V. Yakimenko, Lyudmila S. Karan, and Sergey E. Tkachev

Index