Features

•Presents current understanding on diet, oxidative stress, inflammation, and cancer
•Examines various types of promising nutritional phytochemicals—from in vitro and in vivo studies to clinical studies
•Connects biomarkers, metabolites, and biological activities of the nutritional phytochemicals to the prevention of diseases
•Offers the first of its kind in a book that provides the key mechanistic understanding of the impact of diet on oxidative stress, inflammation, and cancer
•Covers dietary and herbal cancer-preventive compounds, such as vitamins D and E, green tea, curcumin, berries, garlic, selenium, ginseng, flaxseed oil, and fish oil
•Discusses research on epigenetics modification in cancer prevention


Summary


Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals.

Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics.

The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

Table of Contents


Section I: Inflammation, Oxidative Stress, Nutritional Phytochemicals, and Cancer

Overview on Oxidative Stress, Inflammation, Cancer Initiation/Progression, and How to Prevent Carcinogenesis/Cancer
Jong Hun Lee and Ah-Ng Tony Kong

Overview of Obesity, Inflammation, and Cancer
Ximena Paredes-Gonzalez, Tin Oo Khor, Limin Shu, Constance Lay-Lay Saw, and Ah-Ng Tony Kong

Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models: Mechanisms of Carcinogenesis and Prevention
Chung S. Yang, Xiaoxin Chen, and Guang-Yu Yang

Overview of Common Dietary Phytochemicals Possessing Antioxidant Properties through Nrf2
Limin Shu, Chengyue Zhang, and Ah-Ng Tony Kong

Section II: Signal Transduction, Molecular Targets, and Biomarkers of Dietary Cancer-Preventive Phytochemicals

Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals
Ann M. Bode and Zigang Dong

Biomarkers for Diet in Cancer Prevention Studies
Zheng-Yuan Su, Limin Shu, and Ah-Ng Tony Kong

Section III: In Vivo Absorption and Pharmacokinetics of Nutritional Phytochemicals

Metabolism and Transport of Anticancer and Anti-Inflammatory Phytochemicals across the Gastrointestinal Tract
Yong Ma and Ming Hu

Pharmacokinetics of Dietary Isothiocyanates and Flavonoids
Yoshihiko Ito, Shizuo Yamada, and Marilyn E. Morris

Section IV: Vitamins A, D, and E Cancer Prevention, and Clinical Perspective

Retinoic Acid Signaling in Hematopoiesis and Immune Functions, and Options for Chemoprevention
Rodica P. Bunaciu and Andrew Yen

Vitamin D and Inflammation in Cancer: Emerging Concepts
Katrina M. Simmons, Wei-Lin W. Wang, Martin P. R. Tenniswood, and JoEllen Welsh

Vitamin E Family of Compounds and Cancer Prevention
Kimberly Kline, Weiping Yu, Richa Tiwary, and Bob G. Sanders

The Protective Role of Vitamin E in Inflammation and Cancer
Amanda K. Smolarek and Nanjoo Suh

Vitamin D and Cancer: Research Update and Clinical Recommendations
Kathleen M. Wesa and Barrie R. Cassileth

Section V: Omega-3 and Omega-6 Fatty Acids

Plant and Marine Sources of Omega-3 Polyunsaturated Fatty Acids, Inflammation, and Cancer Prevention
Julie K. Mason, Ashleigh K. A. Wiggins, and Lilian U. Thompson

Polyunsaturated Fatty Acids and Cancer Prevention
Janel Suburu and Yong Q. Chen

Anti-Inflammatory and Proresolving Effects of Docosahexaenoic Acid: Implications for Its Chemopreventive Potential
Young-Joon Surh, Na-Young Song, Ha-Na Lee, and Hye-Kyung Na

Section VI: Flavonoids and Polyphenols

Green Tea and Cancer Prevention
Naghma Khan and Hasan Mukhtar

Curcumin from Turmeric Spice, Anti-Inflammatory and Antioxidant Phytochemical, and Cancer Prevention
Tin Oo Khor and Ah-Ng Tony Kong

Flavonoids: Impact on Prostate Cancer and Breast Cancer
James Cardelli, David Coleman, and Katherine D. Crew

Cancer Prevention by Isoflavone
Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar

Anti-Inflammatory Efficacy of Silibinin: Role in Cancer Chemoprevention
Alpna Tyagi, Gagan Deep, and Rajesh Agarwal

Cancer Prevention by Antioxidant Compounds from Berries
Noah P. Zimmerman, Dan Peiffer, and Gary D. Stoner

Section VII: Garlic Organosulfur Compounds and Crucifer Glucusinolates

Garlic and Cancer Prevention
Chi Chen

Molecular Mechanisms of Cancer Chemoprevention with Benzyl Isothiocyanate
Anuradha Sehrawat and Shivendra V. Singh

Suppression of Prostate Carcinogenesis by Dietary Isothiocyanates
Young-Sam Keum

Section VIII: Selenium, Herbal Medicines, Alpha Lipoic Acid, and Cancer Prevention

Cancer Prevention with Selenium: Costly Lessons and Difficult but Bright Future Prospects
Junxuan Lü, Cheng Jiang, and Jinhui Zhang

Chemoprevention of Lung Cancer by Ginseng
Michael S. You, Lucina C. Rouggly, Ming Hu, Zhen Yang, Ming You, and Yian Wang

Anti-Inflammatory Botanical Dietary Supplements for Women’s Health: Role in Breast Cancer Prevention?
Birgit M. Dietz and Judy L. Bolton

PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different Tissues
Wing Lam, Scott Bussom, Zaoli Jiang, Wei Zhang, Fulan Guan, Shwu- Huey Liu, and Yung-Chi Cheng

Lipoic Acid in the Prevention and Treatment of Inflammatory Disease and Cancer
Kate Petersen Shay, Regis F. Moreau, and Tory M. Hagen

Section IX: Epigenetics and Chronic Inflammation

Epigenetic Modifications by Dietary Phytochemicals in Cancer Prevention
Tabitha M. Hardy and Trygve O. Tollefsbol

Nutritional Phytochemicals and the Management of Chronic Inflammation
Laura Marler and John M. Pezzuto