Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions. Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential. Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.

1 Assessment and Management of the Rheumatological Patient
in the Critical Care Unit........................................................................................ 1
David P. D’Cruz and Duncan L.A. Wyncoll
2 Life-Threatening Complications of Systemic Lupus Erythematosus............... 9
Michelle Petri
3 Catastrophic Antiphospholipid Syndrome.......................................................... 19
Maria J. Cuadrado, Giovanni Sanna, Maria Laura Bertolaccini,
and Munther A. Khamashta
4 Complex Situations in Rheumatoid Arthritis..................................................... 27
Miriam García-Arias, Gema Bonilla, Luis Gómez-Carreras,
and Alejandro Balsa
5 Sjögren’s Syndrome: Beyond Sicca Involvement............................................... 45
Manuel Ramos-Casals, Pilar Brito-Zerón, Albert Bové Boada,
and Antoni Sisó-Almirall
6 Systemic Sclerosis: Severe Involvement of Internal Organs............................. 67
Niamh P. Quillinan and Christopher P. Denton
7 Vasculitic Emergencies in Patients with Large-Vessel Vasculitis...................... 89
Kathleen Maksimowicz-McKinnon and Gary S. Hoffman
8 Life-Threatening Presentations of ANCA-Associated Vasculitis...................... 101
Duvuru Geetha and Philip Seo
9 Severe Polyarteritis Nodosa.................................................................................. 119
Loïc Guillevin and Gregory Pugnet
10 Life-Threatening Cryoglobulinemia.................................................................... 133
Soledad Retamozo, Cándido Díaz-Lagares, Xavier Bosch,
Salvatore de Vita, and Manuel Ramos-Casals
11 Behçet’s Syndrome: Clinical Presentations Affecting
Prognosis and Survival.......................................................................................... 163
Emire Seyahi, Koray Tascilar, and Hasan Yazici
12 Myositis: When Weakness Can Kill..................................................................... 185
Patrick Gordon and Ingrid E. Lundberg
13 Complicated Sarcoidosis: Challenges in Dealing
with Severe Manifestations................................................................................... 201
Robert P. Baughman and Hilario Nunes
14 Complex Situations in Patients with Adult-Onset Still’s Disease...................... 221
Petros V. Efthimiou, Manil Kukar, and Olga Petryna
15 Managing Acute and Complex Dermatological Situations................................ 233
Eduardo Fonseca and Rosa M. Fernández-Torres
16 Life-Threatening Autoimmune Hematological Disorders................................. 259
Emmanuel Andrès, Helen Fothergill, and Mustapha Mecili
17 Autoimmune Ear, Nose, and Throat Emergencies............................................. 275
Aharon Kessel, Zahava Vadasz, and Elias Toubi
18 Ophthalmological Emergencies in Rheumatic
and Autoimmune Diseases.................................................................................... 291
Edward Pringle and Miles Stanford
19 Emergencies for the Vascular Surgeon................................................................ 315
Ashish S. Patel and Matthew Waltham
20 Complicated Pregnancies in Patients with Autoimmune
Systemic Diseases................................................................................................... 331
Guillermo Ruiz-Irastorza and Munther A. Khamashta
21 The Complex Management of Viral-Related Autoimmune Diseases................ 345
Dimitrios Vassilopoulos and Spilios Manolakopoulos
22 The Role of Intravenous Immunoglobulins
in the Management of Acute Complex Autoimmune Conditions..................... 259
Rotem Kedar, Yehuda Shoenfeld, and Howard Amital
23 Life-Threatening Complications of Biological Therapies.................................. 375
Ana Campar and David A. Isenberg
Index ............................................................................................................................. 405